A Systematic Genomewide Linkage Study in 353 Sib Pairs with Schizophrenia
نویسندگان
چکیده
منابع مشابه
Multilocus linkage analysis of affected sib pairs.
OBJECTIVE The conventional affected sib pair methods evaluate the linkage information at a locus by considering only marginal information. We describe a multilocus linkage method that uses both the marginal information and information derived from the possible interactions among several disease loci, thereby increasing the significance of loci with modest effects. METHODS Our method is based ...
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Rheumatoid arthritis is a complex disease in which environmental factors interact with genetic factors that influence susceptibility. Incorporating information about related quantitative traits or environmental factors into linkage mapping could therefore greatly improve the efficiency and precision of identifying the disease locus. Using a multipoint linkage approach that allows the incorporat...
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Several theoretical studies have suggested that large samples of randomly ascertained siblings can be efficiently used to ascertain phenotypically extreme individuals and increase power to detect genetic linkage. Phenotypes that can be reliably measured by questionnaire are of obvious utility for such selection strategies, as large numbers of individuals can be contacted without laborious indiv...
متن کاملInference of Identity-by-Descent in Sib Pairs: Analysis with and without Linkage Disequilibrium
In gene mapping, after an initial genome-wide linkage scan, the next step often involves candidate region studies or fine mapping using dense markers. Dense genotyping, however, introduces linkage disequilibrium (LD). Traditional linkage analysis assuming no LD leads to increased false positive rates. Hence, we develop models to incorporate linkage disequilibrium, focusing on the sib pair desig...
متن کامل[Systematic review of the Genomewide Association Studies (GWAS) in schizophrenia].
INTRODUCTION Heritability in schizophrenia can reach up to 80% and the risk in families is 5-10 times higher than in the general population. The large contribution of genetics in this disorder has led to a growing interest in its study. OBJECTIVES To review the findings of genetic studies known as Genomewide Association Studies (GWAS) on schizophrenia. METHOD Systematic search using Pubmed ...
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ژورنال
عنوان ژورنال: The American Journal of Human Genetics
سال: 2003
ISSN: 0002-9297
DOI: 10.1086/380206